Relationship Between Central Auditory Processing Abilities and Working Memory During Adolescence.

Purpose: Adolescence is a period of transformation in humans with changes in the neural physiology at subcortical and cortical levels. However, its significance on auditory processing skills and working memory skills and their association is yet to be well understood. Hence, the current study was designed to evaluate and establish the association between auditory processing skills and working memory abilities in adolescents. Method: A total of 125 adolescents within the age range of 10 to 15 years participated in the current study. All of them had normal hearing sensitivity and no associated obvious peripheral or central deficits. All the participants underwent auditory closure ability assessment using quick speech perception in noise test in Kannada, binaural integration ability assessment using dichotic CV test, and temporal processing assessment using gap detection test. Auditory working memory abilities were assessed using auditory digit span and digit sequencing. Results: Spearman correlation was done to assess the correlation between auditory processing skills and working memory abilities. Results revealed a significant negative correlation between most of the central auditory processing abilities and all the working memory spans. Conclusions: Findings of the current study indicate that individuals with poor working memory abilities have difficulty in auditory processing abilities.

Effectiveness of BBV152/Covaxin and AZD1222/Covishield vaccines against severe COVID-19 and B.1.617.2/Delta variant in India, 2021: a multi-centric hospital-based case-control study.

OBJECTIVES: India introduced BBV152/Covaxin and AZD1222/Covishield vaccines in January 2021. We estimated the effectiveness of these vaccines against severe COVID-19 among individuals aged ≥45 years. METHODS: We did a multi-centric, hospital-based, case-control study between May and July 2021. Cases were severe COVID-19 patients, and controls were COVID-19 negative individuals from 11 hospitals. Vaccine effectiveness (VE) was estimated for complete (2 doses ≥ 14 days) and partial (1 dose ≥ 21 days) vaccination; interval between two vaccine doses and vaccination against the Delta variant. We used the random effects logistic regression model to calculate the adjusted odds ratios (aOR) with a 95% confidence interval (CI) after adjusting for relevant known confounders. RESULTS: We enrolled 1143 cases and 2541 control patients. The VE of complete vaccination was 85% (95% CI: 79-89%) with AZD1222/Covishield and 71% (95% CI: 57-81%) with BBV152/Covaxin. The VE was highest for 6-8 weeks between two doses of AZD1222/Covishield (94%, 95% CI: 86-97%) and BBV152/Covaxin (93%, 95% CI: 34-99%). The VE estimates were similar against the Delta strain and sub-lineages. CONCLUSION: BBV152/Covaxin and AZD1222/Covishield were effective against severe COVID-19 among the Indian population during the period of dominance of the highly transmissible Delta variant in the second wave of the pandemic. An escalation of two-dose coverage with COVID-19 vaccines is critical to reduce severe COVID-19 and further mitigate the pandemic in the country.

Maturation of speech perception in noise abilities during adolescence.

BACKGROUND: Speech perception encompasses the perception of spectro-temporal cues. These cues include temporal envelope, temporal fine structure, and spectral shape of the signal. Extraction of these cues is essential for speech perception and, most importantly, for perceiving speech in the presence of noise (SPIN). Speech perception in noise scores improves with age in children and is crucial in their routine communications, including classroom learning. Though it is established that the speech perception in noise improves with age in children, the age at which SPIN scores become adult-like and the differences in the maturation pattern between the ears remains unclear. The present study aimed to assess and understand the maturation pattern of speech perception in noise abilities during adolescence. METHOD: The study included 146 participants who were divided into six crossectional age groups. Participants were in the age range of 10-15 years and adults of 18-19 years. SPIN was assessed for right and left ears for each of these sub-groups. The scores were compared across the different subgroups for both the ears. RESULTS: Results demonstrated that SPIN scores in the right ear were matured by the age of 10 years and were comparable with the right ear SPIN scores in adults. Pairwise comparison using Bonferroni's corrections for multiple comparisons of left ear SPIN scores revealed that SPIN scores in the left ear become adult-like between 13 and 14 years of age. DISCUSSION: Findings of the current study can be attributed to the morphological changes and differences in the developmental changes across the different regions of the cortex.